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Systemic Lupus Research Studies

We are all in this together

Participating in Lupus Research

We are currently recruiting participants for several research studies.  With the help of research projects like these, more people with lupus are able to live healthier and more active lives.  Doctors are able to diagnose lupus earlier and use more effective therapies to treat patients.  Because of the generosity of research participants, we are learning more about this disease everyday.  Every person counts.

E-mail solvable@northwestern.edu for more information.

The Chicago Lupus Database was established in 1991 as a registry for people with lupus who are interested in research participation.

GENETICS and Lupus (currently not recruiting)

Through a partnership with the University of Alabama and lupus centers around the world, we are currently engaged in research to examine genetic and environmental risk factors for organ damage in people with lupus.  We are now recruiting Caucasian, African-American, and Hispanic men and women at least 19 years of age for this study.  Study participation involves three annual visits that include a blood draw, urinalysis, and physical exam.

SLICC Registry (currently not recruiting)

The purpose of this study is to develop a registry or database of information on a large number of newly diagnosed SLE patients who are followed by the 30 SLICC members over time.  This registry will provide the long term follow-up of a large diverse population of patients using standard methodologies.  This will allow researchers to determine the prevalence and nature of early atherosclerotic coronary artery disease in SLE and to identify associated risk factors.


NUgene is a clinical research project currently being conducted at NMH and NMFF.  The goal of this project is to collect and store genetic samples (DNA) along with associated healthcare information to form a gene bank.  This large bank of samples, currently at 9,600 and growing, is available to researchers who are working to identify genetic contributions to human disease.  This allows the researchers to more easily obtain many samples at one time, facilitating genetic research so it can more quickly impact healthcare in the future.  All samples and information are de-identified before distribution for research. 

Participants in this study have the opportunity to provide Dr. Ramsey-Goldman with access to the information collected from participants through NUgene for research purposes.  This will allow her to do additional research in the future on the role that genes play in lupus.

SOLVABLE: Heart and Bone Study (Currently not recruiting)

The purpose of this study is to find out the effects of lupus on blood vessels and on long-term bone conditions.  Participants are women with lupus (cases) and women without lupus (controls) who complete three study visits over a 5-year period.  Study visits include a carotid ultrasound, bone density test, x-ray of the heart, physical exam (cases), urinalysis, and blood testing (including glucose and cholesterol screening).

Note: Case recruitment for this study is complete.  We are currently only recruiting women without lupus (controls) for this study using a randomized recruitment model.

REACH Project

The lupus research group has taken on a new initiative, the Roadmap for Education and Access to Care for Chicago Hispanic Lupus (REACH LUPUS) Disparities Project which is funded by the ACR to work with a targeted Hispanic-Mexican population in Chicago’s Pilsen community to increase lu-pus awareness where individuals diagnosed with conditions such as lupus that have few recourses for care, follow-up and continued treatment using educational materials. The project has been recently funded and is still in early program development. The project design is multifaceted and will include work provided to the community via support group services and to primary providers by engaging in outreach and education.

Cell Bound Complement Activiation Products for the Monitoring of SLE

The purpose of this study is to establish the performances of Cell Bound Complement Activation Products in (1) monitoring SLE disease activity and predicting flares, and (2) differentiating subjects with SLE from those with other similar rheumatic diseases. Another objective is to identify genetic biomarkers associated with SLE and its’ clinical manifestations. Participation includes a total of 13 study visits consisting of a blood draw, urinalysis, and physical exam.

Characterization of Immune Alterations in SLE using Single Cell Network Profiling (SCNP)

To perform analysis of immune system cellular subsets using peripheral blood samples collected from patients with active SLE during the natural course of disease and treatment and compare SCNP data from these samples with similar data obtained from healthy individuals.

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This page last updated 

March 31, 2014
Feinberg School of Medicine home page

Lupus Research Group
Northwestern University Feinberg School of Medicine

Division of Rheumatology
240 E. Huron, McGaw M300
Chicago, IL 60611

Research Group Phone: 312-503-0247

For clinic appointments, call 312-695-8628


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